The Food and Drug Administration aims to evaluate treatments for rare diseases based on plausible evidence that they would work — without requiring a clinical trial first.

A man with Tourette syndrome shouted a racial slur and other offensive remarks during the BAFTA awards ceremony Sunday. The BBC did not edit out his outbursts in its delayed broadcast.

In a recent video, the Olympic skier credits her surgeon with saving her leg from potential amputation.

Observers watching federal immigration enforcement in Maine who were told by agents they were "domestic terrorists" and would be added to a "database" or "watchlist" are now part of a new federal class action lawsuit.

Forecasters called travel conditions "extremely treacherous" and "nearly impossible" in areas hit hardest by the storm, and air and train traffic is at a standstill in many parts of the region.

Police have arrested Peter Mandelson, a veteran Labour Party politician who served as British ambassador to the U.S., as part of an investigation into his ties with Jeffrey Epstein.

Tuesday marks four years since Russia’s full-scale invasion of Ukraine.

The list of grievances from the colonies to the British Crown eventually became a founding document and the blueprint for American democracy.

The Department of Homeland Security is buying up huge warehouses to detain and process more migrants for deportation.

NPR's reporters on the ground in Italy reflect on a far-flung, jam-packed Winter Olympics.

As Italy cracks down on migration, Milan takes a different path — offering shelter and integration to asylum seekers even as the central government tightens borders and funds deterrence abroad.

President Trump says he is raising global tariffs to 15%. And ahead of the president's address tomorrow, most Americans say the state of the union is not strong, according to an NPR poll.